These pages are intended to give information about my laboratory’s research, publications and people. If you would like to be in touch, please email me at dov.stekel [AT] nottingham.ac.uk. We also post all news from the lab blog to our facebook page and Twitter feed @dovstekellab and you can keep in touch using that.
We use mathematical, computing and statistical techniques to build predictive models for biological systems. There are three main areas of activity:
- Antimicrobial resistance. We use mathematical and computer models at both molecular and population levels to study mechanisms for, and spread of, antimicrobial resistance. Past work has included modelling plasmid regulation, and models for molecular mechanisms for antimicrobial metals, including zinc and mercury. We have also carried out in silico evolution of gene network responses to antimicrobial agents. Current work is focussed on the emergence of antimicrobial resistance in the environment, especially in agriculture.
- Model-driven data analysis. We combine mathematical models with Bayesian methods with the aims of best interpretation of experimental data. We have recently been funded by BBSRC to apply these approaches to bioluminescent reporters and to Biolog Phenotype arrays, with applications in brewing, bioenergy and food safety. We have also taken these approaches into our mechanistic AMR modelling activities.
- Quantitative bioinformatics. We retain an interest in using statistical and machine learning techniques as applied to large scale quantitative data sets from Omics technologies, including transcriptomics, proteomics and metabolomics.
We try, where possible, to work on projects with active collaborations with experimental biologists. While our main focus is on microbiology, we are happy to foster collaborations with scientists working in any area of biology, and this range is reflected in our publications.
We are always happy to hear from individuals who would be interested in Masters, PhD or Fellowship projects in our laboratory. Please email me at dov.stekel [AT] nottingham.ac.uk.
I am Associate Professor of Integrative Systems Biology at the School of Biosciences, University of Nottingham. I studied mathematics at Trinity College, Cambridge and for a D.Phil. at the Department of Zoology, University of Oxford, supervised by Martin Nowak. My D.Phil. topic was on mathematical modeling of T lymphocyte recirculation and virus dynamics. Following my D.Phil., I worked briefly with Boris Vojnovic at the Gray Laboratory, before taking a position in the Bioinformatics group at Glaxo Wellcome Research and Development (as it was), and then as Head of Bioinformatics at Ed Southern‘s microarray company, Oxford Gene Technology. I left OGT after receiving a commission from Cambridge University Press to write Microarray Bioinformatics, and worked as a free-lance bioinformatics consultant during that time. In 2004 I took the position as Lecturer in Bioinformatics at the School of Biosciences, University of Birmingham and in 2009 moved to the University of Nottingham to take my current post.
Photograph thanks to Mike Beard.